Isitofu se-Enrofloxacin

I-Pharmacodynamic Enrofloxacin lichiza elibanzi le-bactericidal elisetyenziswa ngokukodwa kwizilwanyana ze-fluoroquinolone.Kuba e.coli, salmonella, klebsiella, brucella, pasteurella, pleuropneumonia actinobacillus, erysipelas, bacillus proteus, clayey ibhaktiriya kaMnu Charest, suppurative corynebacterium, ukoyiswa kwebhaktiriya ye-pott yegazi, i-staphylococcus aureus, i-mycoplasma, i-mycoplasma, njl njl. kwaye i-streptococcus ibuthathaka, isiphumo esibuthathaka kwibhaktheriya ye-anaerobic.Inesiphumo esicacileyo se-post-antibacterial kwiibhaktheriya ezibuthathaka.Indlela yokusebenza ye-antibacterial yale mveliso kukuthintela ukujikeleza kwe-DNA yebhaktiriya, ukuphazamisa ukuphindaphinda, ukubhalwa kunye nokulungiswa kwe-bacterial DNA recombination, ibhaktheriya ayikwazi ukukhula kwaye ivelise ngokuqhelekileyo kwaye ife.

I-Pharmacokinetics Ichiza lifunxwe ngokukhawuleza nangokupheleleyo ngenaliti ye-intramuscular.I-bioavailability yaba yi-91.9% kwiihagu kunye ne-82% kwiinkomo.Isasazwa ngokubanzi kwizilwanyana kwaye inokungena kwizicubu kunye nolwelo lomzimba kakuhle.Ngaphandle kwe-cerebrospinal fluid, ukuxinwa kweziyobisi phantse kuzo zonke izihlunu kuphezulu kunoko kwiplasma.I-metabolism ephambili ye-hepatic kukususwa kwe-ethyl ye-7-piperazine ring ukuvelisa i-ciprofloxacin, ilandelwa yi-oxidation kunye ne-glucuronic acid yokubopha.Ikakhulu ngezintso (i-renal tubular secretion kunye ne-glomerular filtration) ukukhutshwa, i-15% ~ 50% kwifom yokuqala evela kumchamo.Ukupheliswa kwesiqingatha sobomi benaliti ye-intramuscular yayiyi-5.9 iiyure kwiinkomo zobisi, 1.5 ~ 4.5 iiyure kwiigusha, kunye ne-4.6 iiyure kwiihagu.